A maxipime vial contains 500 mg, 1g or 2g of cefepime activity in the form of a sterile mix of cefepime dihydrochloride monohydrate and larginine. In hemodialysis patients, postdialysis treatment with intravenous antibiotics permits even severe infections to be managed on an outpatient basis. The standard recommended amount is 50 mg per kg about 22. Renal dosage adjustment guidelines for antimicrobials the. Precautions must be taken in the following situations. Mild to moderate uncomplicated or complicated infections.
Oct 02, 2018 maxipime can pass into breast milk and may harm a nursing baby. Nov 01, 2019 maxipime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. Maxipime cefepime hydrochloride injection, powder, for. Your specific cefepime dosage will depend on how much you weigh and the purpose for using the medication, among other factors. The larginine, at an approximate concentration of 707 mgg of cefepime, is added to control the ph of the constituted. Renal dose adjustment guidelines for antimicrobials crrt. By continuing to browse this site you are agreeing to our use of cookies. Maxipime fda prescribing information, side effects and uses. When selecting an antimicrobial dosing regimen for critically ill patients with severe renal failure, the effects of renal failure itself, other acute and chronic disease states, and extracorporeal drug clearance by renal replacement therapies on drug pharmacokinetics should be considered. Renal dose adjustment guidelines for antimicrobials.
Peritoneal dialysis for continuous ambulatory peritoneal dialysis capd, administer recommended doses of cefepime as indicated for the infection and extend the dosing interval to every 48 hours. For children, the dosage is calculated based on the childs weight. Oct 02, 2018 maxipime for injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. Find patient medical information for maxipime intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Maxipime cefepime hydrochloride, usp for injection for. Maxipime cefepime dosing, indications, interactions. Dosage adjustments in patients with renal impairment. Risk may be increased in the presence of renal impairment. Cefepime cep is approved by the food and drug adminstration fda for the treatment. Food and drug administration fda is reminding health care professionals about the need to adjust the dosage of the antibacterial drug cefepime in patients with renal kidney impairment. Maxipime cefepime dosing, indications, interactions, adverse.
In patients with renal impairment in patients who have creatinine clearance less than 60 ml min dose of this drug must be reduced. Maxipime reference guide for safe and effective use from the american society of. It works by killing bacteria or preventing their growth. The recommended doses of maxipime in patients with renal impairment are presented in table 2. When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved. Abacavir abacavir lamivudine abacavir lamivudine zidovudine acarbose acebutolol acetaminophen acetazolamide acetohexamide acetohydroxamic acid acetylsalicylic acid aspirin acrivastine acyclovir adefovir adenosine albuterol inhaled albuterol oral alfentanil alfentanil allopurinol alprazolam alteplase tissuetype plasminogen activator. Cefepime cep is approved by the food and drug adminstration fda for the treatment of febrile neutropenia, empiric therapy of uncomplicated skin and soft tissue infection ssti, complicated intra. Cefepime is a drug from the group of medicines called cephalosporins.
Medscape indicationspecific dosing for maxipime cefepime. Nov 27, 2019 adjust the dose of maxipime in patients with creatinine clearance less than or equal to 60 mlmin to compensate for the slower rate of renal elimination. However, this medicine will not work for colds, flu, or other virus infections. Maxipime is contraindicated in patients who are hypersensitive to this drug or other cephalosporin or penicillin antibiotics. Cefepime is given as an intravenous or intramuscular injection, usually once every 8 or 12 hours. Cvvhd removes solutes including drugs via diffusion. Cefepime is a fourthgeneration cephalosporin with a broad spectrum of action in monotherapy. Cefepime is a newer cephalosporin of iv generation and works against a wide range of bacteria.
Cefepime has an extended spectrum of activity against grampositive and gramnegative bacteria, with greater activity against both types of organism than thirdgeneration agents. We report on the pharmacokinetics of cefepime in postdialysis therapy. Threetimesweekly, postdialysis cefepime therapy in. Cut cefepime dose in kidney disease fda says medpage today. Jun 26, 2012 information on cefepime marketed as maxipime share. Includes dosages for bacterial infection, urinary tract infection, pneumonia and more. If your kidneys do not function well, you may need a lower and less frequent amount. The most current version of the renal dosage adjustment guidelines for antimicrobials and associated. Find patient medical information for maxipime injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Maxipime cefepime hydrochloride, usp is a semisynthetic, broad spectrum, cephalosporin antibiotic for parenteral administration.
Dosage adjustment may be required in cases of impaired renal. Cefepime dosage forms include injection and infusion, and should be administered only by health care team. Side effects of maxipime cefepime hydrochloride for. To reduce the development of drugresistant bacteria and maintain the effectiveness of maxipime and other antibacterial drugs, maxipime should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. This effect is increased when you also use certain other medicines, including. Maxipime is a sterile, dry mixture of cefepime hydrochloride and larginine. The st george hospital renal department peritoneal dialysis committee date. Maxipimetm cefepime hydrochloride, usp for injection. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry.
Ibm micromedex if your symptoms do not improve within a few days, or if they become worse, check with your doctor. Jun 27, 2012 the antibiotic cefepime maxipime may cause a specific type of seizure in patients with kidney impairment when doses are not reduced appropriately, the fda warned. This study evaluated the pharmacokinetics of cefepime in 36 patients with different levels of renal function. Cefepime is a broadspectrum fourthgeneration cephalosporin with in vitro activity similar to that of cefotaxime or ceftriaxone against the common meningeal pathogens h.
Guidelines recommend cefepime plus vancomycin, gentamicin, and rifampin if prosthetic material is present for culturenegative nosocomial endocarditis associated with vascular cannulae or early less than 1 year after surgery prosthetic valve endocarditis. Cefepime for injection should be administered at the same time each day and following the completion of hemodialysis on hemodialysis days. Maxipime 2 g injection composition maxipime cefepime hydrochloride for injection is a cephalosporin antibiotic intended for intramuscular or intravenous administration. Our maxipime side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This document outlines renal function based dose adjustments for adult inpatients and outpatients with renal impairment who are receiving oral and parenteral medications, with the exception of medications defined as chemotherapy for.
Pharmacokinetic and pharmacodynamic parameters were calculated using samples obtained. Cefepime maxipime side effects, dosage, interactions drugs. A 2007 metaanalysis suggested when data of trials were combined, mortality was increased in people treated with cefepime compared with other. Renal department peritoneal dialysis service workplace instruction approved by. Feb 29, 2012 cefepime is excreted mostly via glomerular filtration, and its neurotoxicity has been reported mainly in patients with renal insufficiency. Cefepime is the generic form of the brandname drug maxipime, which is used to treat bacterial infections such as urinary tract infections, pneumonia, and skin infections the prescription.
Adjust the dose of maxipime in patients with creatinine clearance less than or equal to 60 mlmin to compensate for the slower rate of renal elimination. Maxipime is approved for use in children as young as two months old. Pdf pharmacokinetics and pharmacodynamics of cefepime in. It is administered intravenously through a vein or by injection into a. Cefepime hydrochloride is a fourthgeneration cephalosporin that belongs to. This book is distributed under the terms of the creative commons. The dose requires adjustment for patients with renal dysfunction, defined as. Cefepime injection may cause diarrhea, and in some cases it can be severe. Since june 2012, twelve infections were treated with postdialysis cefepime in 9.
Detailed cefepime dosage information for adults and children. Maxipime and other antibacterial drugs, maxipime should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Renal functionbased dose adjustments adult inpatient. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Pharmacokinetics of cefepime during continuous renal. Maxipime injection is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. In these patients, the recommended initial dose of maxipime should be the same as in patients with crcl greater than 60 mlmin except in patients undergoing hemodialysis. Cefepime belongs to antibiotics, used in the treatment of infections. The initial dose of cefepime for patients with renal impairment is the same as for patients with normal renal function. Uncomplicated skin and skin structure infections, bone and joint infections, uncomplicated. This is not a complete list of side effects and others may occur. Cefepime drug monograph pediatric care online aap pointof. Maxipime cefepime hydrochloride dose, indications, adverse.
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